ONE FACTOR RESPONSE SURFACE METHODOLOGY (RSM) FOR THE OPTIMIZATION OF ORAL VENLAFAXINE HCL CONTROLLED RELEASE ORGANOGEL

Objective: The aim of this study was to develop the oral Venlafaxine HCl controlled-release organogel (organogel–CR) by using one-factor response surface methodology (RSM). Methods: In study, Drug-excipient compatibility evaluated FT-IR. A total 14 experimental runs were carried out employing detailed conditions designed a single factor completely randomized design based on used check concentration effect 12-Hydroxy stearic acid (12-HSA) at different cooling rates drug release 10 h (Q10) and after 12 (Q12). Multiple linear regression analysis, analysis variance (ANOVA) graphical representation influence performed expert 12. developed also for viscosity, strength, transition temperature, diffusivity Scanning electron microscopy (SEM). Prepared filled in capsule investigated weight variation, content, erosion vitro study. Results: FT-IR results showed that there no chemical interaction between excipients. SEM photograph indicates highly viscous with 3D network structure. confirmation tests correlation predicted responses (R2 = 0.9937 0.9709). ANOVA suggested calculated F values all dependent variables are greater than tabulated values. optimal point obtained located valid region optimum batch containing 7.9% 12-HSA gradual rate. To validate evolved mathematical models, checkpoint selected its desirability value found be 0.866. Conclusion: Oral controlled fix problem repeated dosing patient noncompliance.